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Growth Hormone

Genryzon 24 mg

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Genryzon Somatrogon Injection, which is a 24 mg/1.2 mL, multi-dose prefilled pen. The medication is intend for subcutaneous injection and is specifically used under the guidance of an endocrinologist.

The packaging indicates it contains Somatrogon, a growth hormone

Description

Genryzon 24 mg/1.2 mL Injection

Genryzon 24 mg/1.2 mL Injection contains Somatrogon, a long-acting recombinant human growth hormone analogue. Doctors use Somatrogon to treat children and adolescents aged 3 years and older who have growth disturbances caused by insufficient secretion of growth hormone. Somatrogon works in a similar way to natural human growth hormone and supports normal bone and muscle growth.

Genryzon 24 mg/1.2 mL comes as a ready-to-use pre-filled pen containing 24 mg of Somatrogon in 1.2 mL of solution. It allows once-weekly administration and does not require reconstitution before use.

Uses of Genryzon 24 mg/1.2 mL Injection

Genryzon 24 mg/1.2 mL Injection is mainly used as growth hormone replacement therapy in eligible children and adolescents.

Growth Hormone Deficiency

Somatrogon replaces the growth hormone that the body does not produce adequately. It helps improve growth and supports normal development in children with confirmed growth hormone deficiency.

Growth Disturbances

Doctors prescribe Somatrogon for children and adolescents from 3 years of age who have growth disturbances due to insufficient secretion of growth hormone.

Once-Weekly Growth Hormone Treatment

Somatrogon has a longer duration of action than conventional daily growth hormone. Genryzon therefore allows eligible patients to receive treatment once a week instead of using a growth hormone injection every day.

Therapeutic Effects of Somatrogon

Somatrogon is a modified form of human growth hormone. It binds to growth hormone receptors and activates biological processes involved in growth and development.

Somatrogon also stimulates the production of insulin-like growth factor-1 (IGF-1), which contributes to bone and tissue growth. It supports protein synthesis and influences fat and carbohydrate metabolism.

Because Somatrogon remains active in the body for longer than conventional growth hormone, Genryzon provides growth hormone activity throughout the week with once-weekly administration.

Interaction with Other Drugs

Certain medicines can affect growth hormone treatment or require additional monitoring when used with Somatrogon.

Corticosteroids

Corticosteroids may reduce some of the growth-promoting effects of growth hormone. Inform the doctor if the child takes corticosteroid medicines regularly.

Diabetes Medicines

Somatrogon can affect glucose metabolism and may change blood sugar levels. Children receiving insulin or other diabetes medicines may require regular blood glucose monitoring.

Thyroid Medicines

Growth hormone treatment can affect thyroid function in some patients. The doctor may monitor thyroid hormone levels during Somatrogon treatment and provide appropriate treatment if thyroid dysfunction develops.

Always tell the doctor about all prescription medicines, over-the-counter medicines, vitamins, and supplements before starting Genryzon.

More Information

Genryzon 24 mg/1.2 mL contains Somatrogon 24 mg in 1.2 mL, giving a concentration of 20 mg/mL. The medicine comes as a multidose, disposable pre-filled pen for subcutaneous injection.

Pre-Filled Pen

The Genryzon 24 mg pen contains Somatrogon in a ready-to-use solution and does not require reconstitution. The pen delivers doses in 0.2 mg increments and can deliver up to 12 mg in a single injection.

Storage

Store Genryzon at 2°C to 8°C in the refrigerator. Do not freeze or shake the pen. Protect it from direct light and heat. After first use, follow the product-specific instructions for refrigerated storage and the permitted in-use period.

Prescription Medicine

Genryzon is a prescription growth hormone treatment. Use Somatrogon only under the supervision of a doctor experienced in managing children with growth hormone deficiency.

How to Administer Genryzon 24 mg/1.2 mL Injection

Genryzon is administered once weekly by subcutaneous injection. The doctor calculates the Somatrogon dose according to the patient’s body weight and treatment response.

Recommended Dose

The recommended Somatrogon dose is 0.66 mg/kg of body weight once weekly. The doctor may individualize the dose according to growth response and other clinical factors.

The 24 mg strength refers to the total amount of Somatrogon contained in the pre-filled pen. It does not mean that the patient should receive 24 mg as a single dose.

Injection Sites

Genryzon can be administered under the skin of the abdomen, thighs, buttocks, or upper arms. Rotate the injection site with each administration to reduce the risk of repeated injection-site reactions.

Weekly Schedule

Administer Genryzon on the same day each week whenever possible. If the weekly injection day needs to change, maintain at least 72 hours between two doses.

Missed Dose

If a dose is missed, follow the instructions provided by the treating doctor. Do not administer an extra dose unless your doctor specifically advises you to do so.

Safety Advice

Breastfeeding

Genryzon is primarily prescribed for children and adolescents with growth hormone deficiency. If breastfeeding is relevant to the patient, discuss Somatrogon use with a doctor before treatment.

Alcohol

Genryzon is intended mainly for children and adolescents, so alcohol exposure is generally not relevant to its intended patient population. Follow the doctor’s advice regarding medicines and other substances used during treatment.

Liver

Tell the doctor if the child has liver disease or impaired liver function. Pfizer’s Genryzon dosing information states that no specific dose recommendation can be made for patients with hepatic impairment because Somatrogon has not been adequately studied in this population.

Kidney

Inform the doctor about any kidney disease before starting Genryzon. No specific dose recommendation is available for patients with renal impairment because Somatrogon has not been adequately studied in this population.

Lungs

Tell the doctor if the child has significant breathing problems or another serious respiratory condition. The doctor will assess the child’s overall health before prescribing Somatrogon.

Driving

Genryzon is intended for children and adolescents and is not generally expected to affect driving ability. If a patient experiences symptoms that affect alertness or coordination, avoid activities requiring full attention and consult a doctor.

Pregnancy

Genryzon is intended for pediatric growth hormone treatment. If pregnancy becomes relevant during treatment, consult a doctor before continuing Somatrogon.

Side Effects of Genryzon 24 mg/1.2 mL Injection

Some patients may experience side effects while using Somatrogon. Possible side effects include:

• Injection-site pain, redness, swelling, or irritation
• Headache
• Fever
• Joint pain
• Muscle pain
• Swelling or fluid retention
• Changes in thyroid function
• Increased blood sugar
• Injection-site reactions
• Development of antibodies against Somatrogon

Injection-site reactions are among the commonly reported effects of Somatrogon. Tell the doctor if any side effect persists, becomes severe, or interferes with normal activities.

Serious Side Effects

Seek prompt medical attention if the patient develops severe or persistent headache, vision changes, significant swelling, breathing difficulty, or symptoms of a serious allergic reaction.

Hip or Knee Pain

Inform the doctor if a child develops persistent hip or knee pain, starts limping, or shows changes in walking. These symptoms require medical evaluation during growth hormone treatment.

Word of Advice

Use Genryzon 24 mg/1.2 mL Injection (Somatrogon) exactly as prescribed by the doctor. Do not change the dose or injection schedule without medical advice.

Keep the Genryzon pen refrigerated at 2°C to 8°C and do not freeze or shake it. Use a new sterile needle for every injection and safely dispose of the needle after use. Never share the pre-filled pen or needles with another person.

Regular follow-up appointments are important during Somatrogon treatment. The doctor may monitor height, growth rate, IGF-1 levels, thyroid function, blood glucose, and other relevant health parameters.