Gonal-F

 1,500.0 19,000.0 Inc GST

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Gonal-F

 1,500.0 19,000.0 Inc GST

MERCK SERONO

GENERIC NAME : FOLLITROPIN ALFA

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Description

Gonal-F

MERCK SERONO

GENERIC NAME : FOLLITROPIN ALFA

Gonal-f (follitropin alfa for injection) is a human follicle stimulating hormone (FSH) readiness of recombinant DNA origin, which comprises of two non-covalently linked, non-identical glycoproteins assigned as the α-and β-subunits. The α-and β-subunits have 92 and 111 amino acids, separately, and their essential and tertiary structure are indistinguishable from those of human follicle stimulating hormone. Recombinant FSH creation happens in hereditarily changed Chinese Hamster Ovary (CHO) cells refined in bioreactors. Purification by immunochromatography using an antibody explicitly restricting FSH brings about a highly purified preparation with a consistent FSH isoform profile, and a high specific activity. The biological movement of follitropin alfa is dictated by estimating the expansion in ovary weight in female rats. The in vivo biological movement of follitropin alfa has been aligned against the first International Standard for Recombinant Human Follicle Stimulation Hormone set up in 1995 by the Expert Committee on Biological Standards of the World Health Organization. Gonal-f® contains no luteinizing hormone (LH) movement. In light of accessible information got from physico-chemical tests and bioassays, follitropin alfa and follitropin beta, another recombinant follicle stimulating hormone item, are undefined.

Gonal-f is a sterile, lyophilized powder planned for subcutaneous injection after reconstitution.

Each Gonal-f Multi-Dose vial is loaded up with 600 IU (44 mcg) or 1200 IU (87 mcg) follitropin alfa to convey 450 IU (33 mcg) or 1050 IU (77 mcg) follitropin alfa, respectively, and contains 30 mg sucrose, 1.11 mg dibasic sodium phosphate dihydrate and 0.45 mg monobasic sodium phosphate monohydrate. Ophosphoric acid as well as sodium hydroxide might be used preceding lyophilization for pH change. Multiple Dose vials are reconstituted with Bacteriostatic Water for Injection (0.9% benzyl liquor), USP.

Under current storage conditions, Gonal-f® may contain up to 10% of oxidized follitropin alfa.

What does Gonal F do?

GONAL-f is given to stimulate the ovaries to deliver more than each egg in turn; adult women with serious inadequacy (low degrees) of luteinising hormone (LH) and follicle stimulating hormone (FSH).

Does Gonal F cause mood swings?

Puregon and Gonal-F are prescribed for ovulation induction in ladies undertaking IVF to select various eggs. Most regular side effects sleepiness, skin redness over the injection site, stomach delicacy and swelling, breast tenderness, mood swings, queasiness and dizziness.

How long does Gonal F take to work?

Throughout the span of treatment, dosages of Gonal-f may go up to 300 IU every day relying upon the individual patient reaction. Gonal-f should be managed until sufficient follicular advancement is shown by serum estradiol and vaginal ultrasonography. A reaction is for the most part obvious following 5 to 7 days.

Does Gonal F make you gain weight?

skin break out • some breast development • weight gain These are common side effects. Tell your doctor if you notice whatever else that is causing you to feel unwell. Opposite results not recorded above may also happen in certain patients. Before using, store GONAL-f in the first package at 2°C to 8°C (Refrigerate.

Does Gonal F injection hurt?

Most importantly, not every woman finds the shots painful, so that is something to remember. For most patients, the injections aren't pleasant, but they are speedy and any discomfort is over in almost no time.

What is GONAL-F and how is it used?

GONAL-F is a professionally prescribed medication containing follicle-stimulating hormone (FSH).

GONAL-F is used in:

infertile ladies to:

  • assist healthy ovaries with creating (develop) and release an egg to assist you with getting pregnant
  • cause your ovaries to make various (multiple) eggs as a component of an Assisted Reproductive Technology (ART) program

infertile men to:

  • help create and produce mature sperm.

What are the possible side effects of GONAL-F?

GONAL-F may cause serious side effects in women and men, including:

severe hypersensitive responses. Ladies or men who have used GONAL-F in the past may have an extreme hypersensitive response immediately when they use GONAL-F once more. This serious allergic reaction may lead to death. If you have any of the accompanying symptoms of an extreme hypersensitive response, stop using GONAL-F and go to the nearest medical clinic trauma center immediately:

  • shortness of breath
  • swelling of your face
  • itchy, red knocks or rash on your skin (hives)

Lung issues. GONAL-F may cause genuine lung issues remembering fluid for your lungs (atelectasis), inconvenience breathing (intense respiratory pain disorder), and deteriorating of asthma.

Blood clots. GONAL F may expand your opportunity of having blood clumps in your veins. Blood clumps can cause:

  • vein issues (thrombophlebitis)
  • stroke
  • loss of your arm or leg
  • blood cluster in your lung (aspiratory embolus)
  • cardiovascular failure

GONAL F may cause genuine results in ladies, including:

ovarian hyperstimulation syndrome (OHSS). OHSS is both a genuine and normal result. Using GONAL-F may cause OHSS. OHSS is a genuine ailment that can happen when your ovaries produce an excessive number of eggs (overstimulated). OHSS can make liquid out of nowhere develop in the region of your stomach, chest, and heart, and can cause blood clumps to form. In uncommon cases OHSS has caused death. OHSS may also occur after you stop using GONAL-F. stop using GONAL-F and summon your medical services supplier right away if you have symptoms of OHSS, including:

  • trouble breathing
  • extreme lower stomach (pelvic) area pain
  • weight gain
  • sickness
  • vomiting
  • diarrhea
  • diminished urine output

Pregnancy with and birth of multiple babies. GONAL-F may increase your chance of having a pregnancy with more than 1 baby. Having a pregnancy and giving birth to more than 1 baby at a time increases the health risk for you and your babies. Your healthcare provider should tell you about your chances of multiple births.

Twisting (torsion) of your ovary. GONAL-F may increase the chance of your ovary twisting if you already have certain conditions such as OHSS, pregnancy and previous abdominal surgery. Twisting of your ovary may lead to blood flow being cut off to your ovary.

Ovaries that are too large. GONAL-F may cause your ovaries to be abnormally large. Symptoms of large ovaries include bloating or pain in your lower stomach (pelvic) area.

Birth defects. A baby born after an ART cycle may have an increased chance of having birth defects. Your chances of having a baby with birth defects may increase depending on:

  • your age
  • certain sperm issues
  • your genetic background and that of your accomplice
  • a pregnancy with more than 1 infant at a time

Ectopic (pregnancy outside your belly). GONAL-F may expand your opportunity of having a pregnancy that is unusually outside of your belly. Your possibility of having a pregnancy outside of your belly is expanded if you also have fallopian tube issues. Summon your medical care supplier right away if you have indications of an ectopic pregnancy including:

  • stomach or pelvic agony particularly on one side
  • shoulder pain
  • neck pain
  • rectal pain
  • nausea and vomiting

Unnatural birth cycle. Your possibility of loss of an early pregnancy might be expanded on the off chance that you experienced issues getting pregnant.

Tumors of the ovary. If you have used meds like GONAL-F more than 1 opportunity to get pregnant, you may have an expanded possibility of having tumors in your ovary(ies) (counting malignancy).

Common side effects of GONAL F include:

in women:

  • ovarian cyst
  • headache
  • OHSS
  • stomach pain
  • pelvic pain
  • nausea
  • gas
  • bleeding between periods

in men:

  • skin problems
  • breast enlargement
  • injection site pain
  • seborrhea
  • tiredness

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of GONAL-F. For more information, ask your healthcare provider.

Additional information

PACKING

300 IU/0.5ML – 1 PEN, 75 IU – 1PFS INJ, 900 IU – 1PEN INJ

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