#Xbira-250Mg Tab

 28,500.0  24,800.0 Inc GST-13%

Sale!

#Xbira-250Mg Tab

 28,500.0  24,800.0 Inc GST-13%

CIPLA ONCO CARE

PACKING : 1X120

GENERIC NAME : ABIRATERONE ACETATE

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Description

Xbira-250Mg Tab

CIPLA ONCO CARE

PACKING : 1X120

GENERIC NAME : ABIRATERONE ACETATE

xbira 250mg

What is Xbira ?

XBIRA 250mg – Abiraterone Acetate is a drug used in combination with prednisone in metastatic castration-resistant prostate cancer (formerly hormone-resistant prostate cancer) which is a prostate cancer not responding to androgen deprivation or treatment with anti-androgens. XBIRA is a CYP17 inhibitor indicated in combination with prednisone for the treatment of patients with metastatic CRPC who have received prior chemotherapy containing docetaxel .

How it works ?

Abiraterone Acetate decreased serum testosterone and other androgens in patients in the placebo-controlled Phase 3 clinical trials. It is not necessary to monitor the effect  on serum testosterone levels.
Changes in serum prostate-specific antigen (PSA) levels may be observed, but have not been shown to correlate with clinical benefit in individual patients.Abiraterone Inhibits 17 Α-Hydroxylase/C17,20 Lyase (CYP17A1), An Enzyme Which Is Expressed In Testicular, Adrenal, And Prostatic Tumor Tissues. CYP17 Catalyzes Two Sequential Reactions: (A) The Conversion Of Pregnenolone And Progesterone To Their 17-Α-Hydroxy Derivatives By Its 17 Α-Hydroxylase Activity, And (B) The Subsequent Formation Of Dehydroepiandrosterone (DHEA) And Androstenedione, Respectively, By Its C17,20 Lyase Activity. DHEA And Androstenedione Are Androgens And Precursors Of Testosterone. Inhibition Of CYP17 Activity By Abiraterone Thus Decreases Circulating Levels Of Testosterone.

How to take it’s dosage?

The recommended dose of these tablets is 1000mg (four 250mg tablets) administered orally once daily in combination with Prednisone 5mg administered orally twice daily. Tablets must be taken on an empty stomach. No food should be consumed for at least 2 hours before the dose of  tablets is taken and for at least 1 hour after the dose of XBIRA tablets is taken. The tablets should be swallowed whole with water and not to be crushed or chewed.

Prominent side effects .

  • Hypertension
  • Diarrhea
  • Anti-Irritation
  • Fluid Retention (Edema)
  • Hypokalemia

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