Dupixent 300mg
₹ 0.00₹ 0.00
- Brand: Dupixent
- Active Ingredient: Dupilumab
- Strength: 300 mg/2 mL
- Dosage Form: Solution for injection
- Drug Class: Immunomodulator / Interleukin inhibitor
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Description
Introduction to Dupixent 300mg Injection
Dupixent 300mg Injection is a biological medicine that contains the active ingredient Dupilumab. It belongs to a group of medicines called interleukin inhibitors. Dupilumab blocks the activity of interleukin-4 (IL-4) and interleukin-13 (IL-13), two proteins that play an important role in type 2 inflammation.
Doctors use Dupixent to manage certain inflammatory conditions, including moderate-to-severe atopic dermatitis, asthma, chronic rhinosinusitis with nasal polyposis, and other approved conditions depending on the patient’s age and local prescribing guidelines.
Dupixent 300mg Injection is supplied as a solution for subcutaneous injection. Each 300mg pre-filled syringe contains 300mg of Dupilumab in 2mL of solution.
Do not use Dupixent if you have a known serious allergy to Dupilumab or any of its ingredients. Tell your doctor about your medical history and all medicines you currently take before starting treatment.
Your doctor may also advise you to continue other medicines, such as topical corticosteroids or asthma medicines, unless they specifically tell you to stop them. Do not discontinue corticosteroids suddenly without medical advice.
Uses of Dupixent 300mg Injection
Dupixent 300mg Injection contains Dupilumab and helps manage certain inflammatory diseases driven by type 2 inflammation.
Dupixent 300mg Injection may be used for:
- Moderate-to-severe atopic dermatitis
- Moderate-to-severe asthma with certain type 2 inflammatory features
- Chronic rhinosinusitis with nasal polyposis
- Eosinophilic esophagitis
- Prurigo nodularis
- Other approved Dupilumab indications depending on age, medical condition, and local regulatory approval
The exact approved uses can vary by country and patient age. In India, Sanofi’s product information provides prescribing information for Dupixent, while current U.S. labeling includes additional approved indications.
How does Dupilumab help treat these conditions?
Dupilumab blocks the IL-4 receptor alpha (IL-4Rα) subunit. This action inhibits signaling from both IL-4 and IL-13.
By reducing these inflammatory signals, Dupilumab can help reduce inflammation and symptoms associated with conditions such as atopic dermatitis, asthma, and other type 2 inflammatory diseases.
Therapeutic Effects of Dupixent 300mg Injection
Dupixent contains Dupilumab, a fully human monoclonal antibody. Dupilumab specifically targets the IL-4Rα receptor and blocks IL-4 and IL-13 signaling.
How does Dupilumab work?
IL-4 and IL-13 contribute to type 2 inflammation. This inflammation can cause skin inflammation, itching, airway inflammation, and other symptoms depending on the underlying disease.
Dupilumab binds to IL-4Rα and prevents IL-4 and IL-13 from sending their inflammatory signals. This mechanism helps reduce type 2 inflammation and can improve disease-related symptoms.
Interaction of Dupixent 300mg Injection with Other Drugs
Tell your doctor about every medicine you take before starting Dupixent treatment. This includes prescription medicines, over-the-counter medicines, vitamins, and herbal supplements.
Important medicine interactions
Dupilumab does not have the same broad drug-interaction profile as many conventional medicines. However, your doctor should still review your complete treatment plan before you start Dupixent.
Do not suddenly stop oral, inhaled, or topical corticosteroids when you begin Dupilumab treatment. Your doctor will decide whether and how to reduce corticosteroid therapy.
Vaccines during Dupixent treatment
Tell your doctor about your vaccination history before starting Dupixent. Current prescribing information advises avoiding live vaccines during Dupixent treatment. Your healthcare provider can determine which vaccines are appropriate for you.
More Information about Dupixent 300mg Injection
- Dupixent 300mg Injection contains Dupilumab.
- Each 300mg pre-filled syringe contains 300mg of Dupilumab in 2mL solution.
- Dupixent comes as a solution for subcutaneous injection.
- Store Dupixent as directed on the product label.
- Keep Dupixent out of the reach of children.
- Do not use the medicine after the expiry date.
- Healthcare professionals should provide appropriate training before patients or caregivers administer Dupixent at home.
How to Administer Dupixent 300mg Injection
A healthcare professional can administer Dupixent by subcutaneous injection. After receiving proper training, some patients or caregivers may administer Dupixent at home using the appropriate pre-filled syringe or pen.
Dupixent dosage
The Dupixent dose depends on the condition being treated, the patient’s age, body weight, and other clinical factors.
For adults with moderate-to-severe atopic dermatitis, the usual regimen starts with a 600mg loading dose, given as two 300mg injections, followed by 300mg every two weeks.
For other conditions, the dose and frequency can differ. For example, adults with chronic rhinosinusitis with nasal polyps generally receive 300mg every two weeks, while some patients with eosinophilic esophagitis receive Dupilumab according to their age and body weight.
Your doctor will select the appropriate Dupilumab dose for your condition. Do not change the dose or injection schedule yourself.
Dupixent injection sites
Dupixent can be injected under the skin of the thigh or abdomen, avoiding the area around the navel. A caregiver can administer the injection into the outer area of the upper arm.
Choose a different injection site each time to reduce local irritation. Follow the instructions provided by your healthcare professional and the product’s instructions for use.
Safety Advice for Dupixent 300mg Injection
Breastfeeding
Consult your doctor.
Tell your doctor if you are breastfeeding or planning to breastfeed. Your doctor will assess your condition and decide whether you should continue Dupilumab treatment while breastfeeding.
Alcohol
Consult your doctor.
There is no specific alcohol-related warning in the prescribing information for Dupilumab. However, discuss alcohol consumption with your doctor based on your medical condition and other medicines.
Liver
Consult your doctor.
Tell your doctor if you have liver disease or any other chronic medical condition. Your doctor will consider your complete medical history before prescribing Dupixent.
Kidney
Consult your doctor.
Inform your doctor if you have kidney problems. Your healthcare provider will consider your overall health and other medicines before starting Dupilumab.
Lungs
Consult your doctor.
Dupixent can help manage certain forms of asthma and other respiratory inflammatory conditions. However, Dupixent is not a rescue medicine for sudden breathing problems or acute bronchospasm. Keep your prescribed rescue medicine available if your doctor has recommended one.
Driving
Safe/Consult your doctor.
Dupixent does not usually affect alertness or coordination. However, avoid driving if your medical condition or any side effect makes you feel dizzy, weak, or unable to concentrate.
Pregnancy
Consult your doctor.
Tell your doctor if you are pregnant, think you may be pregnant, or plan to become pregnant. Your doctor will assess the benefits and potential risks of Dupilumab treatment during pregnancy.
Side Effects of Dupixent 300mg Injection
Dupixent can cause side effects, although not everyone experiences them. Some reactions may occur around the injection site, while others can affect the eyes or immune system.
Common side effects of Dupixent
Common side effects may include:
- Injection-site reactions
- Conjunctivitis
- Eye irritation
- Eyelid inflammation
- Cold sores in some patients
- Eosinophilia
- Joint pain in some patients
- Headache
- Sore throat
- Symptoms related to the underlying condition
The side effects can vary depending on the condition for which you receive Dupilumab.
Serious side effects of Dupixent
Seek immediate medical attention if you develop:
- Severe allergic reactions
- Difficulty breathing
- Swelling of the face, lips, mouth, tongue, or throat
- Severe rash
- Widespread itching or hives
- Symptoms of serum sickness or serum sickness-like reactions
- Severe eye pain or changes in vision
Dupilumab can cause hypersensitivity reactions, including anaphylaxis and angioedema. Stop Dupixent and seek immediate medical care if you develop signs of a severe allergic reaction.
Eye-related side effects
Dupixent can cause or worsen certain eye problems, including conjunctivitis and keratitis.
Tell your doctor if you develop new or worsening eye redness, itching, irritation, discharge, eye pain, or changes in vision during treatment. Your doctor may recommend an eye examination.
Word of Advice
Dupixent 300mg Injection contains Dupilumab and works by blocking IL-4 and IL-13 signaling. Use Dupixent exactly as prescribed by your doctor.
Do not stop Dupilumab or other medicines for your condition without discussing the change with your healthcare provider. If you use corticosteroids, your doctor will guide you on any dose reduction.
Important precautions while using Dupixent
- Tell your doctor if you have previously experienced an allergic reaction to Dupilumab.
- Inform your doctor about all medicines, vitamins, and supplements you take.
- Tell your doctor if you develop new or worsening eye symptoms.
- Avoid live vaccines unless your doctor specifically advises otherwise.
- Keep your prescribed rescue inhaler available if you use Dupixent for asthma.
- Do not use Dupixent to treat sudden asthma attacks.
- Follow the correct injection technique if you administer Dupilumab at home.
- Change the injection site with each dose.
- Seek immediate medical attention if you develop symptoms of a severe allergic reaction.
Dupixent 300mg Injection, containing Dupilumab, helps control several inflammatory conditions by blocking IL-4 and IL-13 signaling. Your doctor will determine whether Dupilumab is suitable for you based on your condition, age, treatment history, and overall health.
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