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Oncology

Jemperli 500mg Injection

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Brand: Jemperli

Generic: Dostarlimab-gxly

Manufacturer: GlaxoSmithKline Pharmaceuticals

Drug class: immune checkpoint inhibitors, specifically PD-1 (programmed death receptor-1) inhibitors and monoclonal antibodies.

Description

Introduction to Jemperli 500mg Injection

Jemperli 500mg Injection contains dostarlimab-gxly and is developed by GlaxoSmithKline (GSK). It is an immunotherapy medicine used to treat certain types of cancer in adults.

Jemperli is used for mismatch repair deficient (dMMR) recurrent or advanced endometrial cancer that has returned or worsened after treatment with platinum-based chemotherapy. It may also be used for certain dMMR solid tumours that have progressed after previous treatment when there are no suitable alternative treatment options.

Jemperli works by blocking the PD-1 (programmed death receptor-1) pathway. Some cancer cells use this pathway to avoid being detected by the immune system. By blocking PD-1, Jemperli helps the immune system recognise and attack cancer cells.

Jemperli 500mg Injection is given as an intravenous (IV) infusion by a healthcare professional in a hospital or specialised cancer treatment centre.

Uses of Jemperli 500mg Injection

Jemperli 500mg Injection is used for:

• Treating dMMR recurrent or advanced endometrial cancer after platinum-based chemotherapy.
• Treating certain dMMR solid tumours in adults whose cancer has progressed after previous treatment and who have no suitable alternative treatment options.
• Treating advanced or recurrent endometrial cancer for the first time, when used together with chemotherapy.

Storage

• Store the injection in a refrigerator at 2°C to 8°C.
• Do not freeze the vial.
• Keep it protected from direct sunlight and in its original carton until use.
• After dilution for infusion, store it at 2°C to 8°C and use it within 24 hours.
• Keep the medicine out of reach of children.

Safety Advice for Jemperli 500mg Injection

Pregnancy

Consult Your Doctor

Jemperli may harm an unborn baby. Women who can become pregnant should use effective birth control during treatment and for at least 4 months after the last dose.

Breastfeeding

Consult Your Doctor

Breastfeeding is not recommended while receiving Jemperli and for at least 4 months after the last dose.

Lungs

Consult Your Doctor

Jemperli may cause lung inflammation (pneumonitis). Tell your doctor immediately if you develop a new or worsening cough, chest pain, shortness of breath, or difficulty breathing.

Liver

Consult Your Doctor

Jemperli may cause liver inflammation. Contact your doctor if you notice signs of liver problems, such as yellowing of the skin or eyes.

Alcohol

Consult Your Doctor

Talk to your doctor before drinking alcohol during treatment. Alcohol may increase tiredness or affect other medicines you are taking.

Driving

Consult Your Doctor

Jemperli may cause tiredness, dizziness, or other symptoms that can affect your ability to drive. Avoid driving or using machinery if you experience these effects.

FAQ

Q1. What is Jemperli 500mg Injection used for?

Jemperli 500mg Injection is used to treat dMMR recurrent or advanced endometrial cancer and certain other dMMR solid tumours that have worsened after earlier treatment.

Q2. How does Jemperli 500mg Injection work?

Jemperli contains dostarlimab-gxly, which is a PD-1 inhibitor. It helps the immune system recognise cancer cells and attack them by blocking the PD-1 pathway that cancer cells can use to avoid the body’s immune response.

Q3. What does dMMR mean?

dMMR means deficient mismatch repair. It is a condition where cancer cells have problems repairing damaged DNA. Cancers with dMMR may respond well to medicines such as Jemperli that help the immune system fight cancer.

Q4. How is Jemperli 500mg Injection given?

Jemperli is given as an intravenous (IV) infusion by a trained healthcare professional. The infusion usually takes about 30 minutes and is given in a hospital or cancer treatment centre.

Q5. What are the common side effects of Jemperli?

Common side effects may include tiredness, nausea, anaemia, and diarrhoea. Jemperli may also cause immune-related side effects that can affect organs such as the liver, lungs, skin, or thyroid and other hormone-producing glands.