Tanstrive 160Mg Tablet
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Brand: Tanstrive
Generic: Selpercatinib
Manufacturer: Eli Lilly
Drug class: Protein kinase inhibitor / Selective RET inhibitor.
Description
Introduction to Tanstrive 160mg Tablet
Tanstrive 160mg Tablet contains selpercatinib, a targeted cancer medicine called a kinase inhibitor. It works by blocking abnormal RET proteins, which can help cancer cells grow and spread.
Tanstrive 160mg Tablet is used to treat certain RET-positive cancers, including some types of lung cancer, thyroid cancer, and other solid tumours.
Do not take Tanstrive if you are allergic to selpercatinib or any of its ingredients. Before treatment, your doctor will perform tests to check whether your cancer has a specific RET gene mutation or fusion.
Tell your doctor if you have liver problems, high blood pressure, heart problems, or any other medical condition. Also inform your doctor if you are pregnant, planning to become pregnant, breastfeeding, or taking any other medicines or supplements.
Uses of Tanstrive 160mg Tablet
Tanstrive 160mg Tablet may be used to treat:
- RET fusion-positive non-small cell lung cancer (NSCLC)
- RET-mutant medullary thyroid cancer (MTC)
- RET fusion-positive thyroid cancer that has not responded adequately to radioactive iodine
- RET fusion-positive solid tumours that have progressed after previous treatment or when there are no suitable alternative treatment options
Your doctor will recommend Tanstrive only when the required RET mutation or fusion is confirmed.
How Tanstrive 160mg Tablet Works
RET is a protein that helps cells grow and divide. Certain changes in the RET gene can make this protein overactive, causing cancer cells to grow uncontrollably.
Tanstrive contains selpercatinib, which blocks abnormal RET signalling. This can help slow down the growth and spread of cancer cells.
Interaction of Tanstrive 160mg Tablet with Other Medicines
Tell your doctor about all the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, nutritional supplements, and herbal products.
Some medicines can affect how selpercatinib is broken down in the body. In particular, medicines that affect the CYP3A enzyme may change the amount of selpercatinib in your blood.
If you are taking certain CYP3A inhibitors, your doctor may need to adjust your Tanstrive dose. Do not start or stop any medicine without first speaking with your doctor.
Storage
- Keep Tanstrive 160mg Tablet out of the reach and sight of children.
- Store the medicine at a temperature not above 25°C.
- Keep the tablets in their original packaging unless your pharmacist advises otherwise.
- Do not use the medicine after its expiry date.
How to Take Tanstrive 160mg Tablet
Take Tanstrive exactly as prescribed by your doctor.
The recommended dose of selpercatinib depends on your body weight and medical condition. Patients weighing less than 50 kg are generally prescribed 120 mg twice daily, while patients weighing 50 kg or more are generally prescribed 160 mg twice daily.
Swallow the tablet whole with water. Do not crush, chew, or break the tablet.
Try to take your doses at approximately the same times every day. Treatment is usually continued until the cancer progresses or side effects become unacceptable, unless your doctor recommends stopping earlier.
If you miss a dose, follow your doctor’s instructions. Do not take a double dose to make up for a missed dose.
Safety Advice
Pregnancy
Consult Your Doctor
Tanstrive may harm an unborn baby. Tell your doctor if you are pregnant, think you may be pregnant, or are planning to become pregnant.
Women who can become pregnant should discuss effective contraception with their doctor before starting treatment.
Breastfeeding
Consult Your Doctor
It is not known whether selpercatinib passes into breast milk. Do not breastfeed while taking Tanstrive unless your doctor specifically advises you to do so.
Lungs
Consult Your Doctor
Tanstrive may rarely cause serious lung problems, including interstitial lung disease (ILD) or pneumonitis.
Contact your doctor immediately if you develop:
- New or worsening cough
- Shortness of breath
- Difficulty breathing
- Fever
Prompt medical attention may be necessary.
Liver
Consult Your Doctor
Tanstrive may affect liver function and can cause increased liver enzymes.
Tell your doctor if you have liver disease before starting treatment. Your doctor may perform regular liver function tests and adjust your dose if necessary.
Contact your doctor if you notice symptoms such as yellowing of the skin or eyes, dark urine, or pain in the upper right side of the abdomen.
Alcohol
Consult Your Doctor
The effects of alcohol while taking Tanstrive are not fully known. Ask your doctor whether it is safe for you to drink alcohol during treatment.
Driving
Use Caution
Tanstrive may cause tiredness or dizziness in some people. These effects may affect your concentration and ability to drive or operate machinery.
Avoid driving if you feel dizzy, tired, or unable to concentrate properly.
Side Effects of Tanstrive 160mg Tablet
Like all medicines, Tanstrive 160mg Tablet can cause side effects, although not everyone experiences them.
Serious Side Effects
Seek medical attention if you develop symptoms of a serious side effect, such as:
- Liver problems: Yellowing of the skin or eyes, dark urine, or pain in the upper right side of the abdomen
- Abnormal heart rhythm: Chest pain, shortness of breath, dizziness, fainting, or a fast or irregular heartbeat
- Severe bleeding: Unusual or heavy bleeding, or a sudden severe headache
- Serious allergic or skin reactions: Severe rash, blistering, peeling skin, or sores in the mouth
Common Side Effects
Common side effects may include:
- High blood pressure
- Increased liver enzyme levels
- Tiredness or fatigue
- Diarrhoea
- Swelling or fluid retention
- Changes in electrolyte levels shown in blood tests
Tell your doctor if any side effect becomes severe, persistent, or bothersome.
Expert Tips
- Take Tanstrive 160mg Tablet exactly as prescribed by your doctor.
- Take your doses at approximately the same time each day.
- Do not crush or chew the tablets.
- Keep your regular appointments for blood pressure and liver function monitoring.
- Tell your doctor if you develop symptoms of liver problems, breathing difficulties, heart rhythm changes, or unusual bleeding.
- Inform your doctor about all medicines, vitamins, supplements, and herbal products you take.
- Do not change your dose or stop treatment without medical advice.
- If you have any questions or concerns about Tanstrive, speak with your doctor or pharmacist.
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